11/12/2022 0 Comments Farsky seedsHistological aberration induced in renal tissue after chronic administration of HFD was also reduced by vitexin. The Western blot analysis suggested that alteration in renal NF-κB, IκBα, nephrin, AMPK, and ACC phosphorylation levels were effectively restored by vitexin treatment. HFD-induced increased renal oxido-nitrosative stress, and pro-inflammatory cytokines levels were significantly inhibited by vitexin. Obesity was induced in male C57BL/6 mice by chronic administration of HFD, and mice were concomitantly treated with vitexin (15, 30, and 60 mg/kg, p.o.). The present investigation aimed to evaluate the possible mechanism of action of vitexin on obesity-induced DN in a high-fat diet (HFD)-fed experimental C57BL/6 mice model. Obesity is one of the most critical risk factors for diabetes mellitus and plays a significant role in diabetic nephropathy (DN). Although, the magnitude of these effects was similar in both groups. Cinnamon seemed to have more effect on both anthropometric (BMI & WC) and biochemical (FPG, HbA1c, serum Insulin, serum cholesterol, HDL & LDL) parameters, as compared to Fenugreek, which had effect on WC, FPG, HbA1c, serum cholesterol and TG only. BMI, WC and WHR were also studied in all phases of the study. Serum levels of FPG, HbA1c, fasting insulin levels, lipid profile were measured at baseline and at the end of 2nd and 3rd phases. Subjects, from both genders, were within the age range of 40-65 years. Study was carried out in three phases: Phase I, baseline Phase II, after 90 days and Pahse III at end of washout period. Subjects were selected from Pakistan Institute of Medical Sciences Hospital, Islamabad. FARSKY SEEDS TRIALA randomized controlled trial was done to compare effects of Fenugreek and Cinnamon on treatment of newly diagnosed cases of T2 DM. This cost-effective way of managing T2DM in developing world might prove very beneficial. Clinical evidence suggests that T2DM and its complications can be prevented through regular intake of functional foods.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |